Striker Toni Martinez could make his debut for Oxford in their FA Cup fourth-round clash with Newcastle.
Martinez joined the club on loan from West Ham on Monday and is eligible to play in the competition.
But boss Michael Appleton may well decide to stick with the team that beat Rochdale 4-0 in League One last weekend.
Defenders Christian Ribeiro and Sam Long are back in training after lengthy injury absences and are set for a run-out in Monday's friendly against Vancouver Whitecaps.
Newcastle boss Rafael Benitez will use the depth of his squad once again as he attempts to manage the dual demands of the FA Cup and the quest for promotion back to the Premier League.
Benitez made eight changes for the third-round replay victory over Birmingham, handing debuts to youngsters Stuart Findlay, Dan Barlaser and Yasin Ben El-Mhanni, and is likely to shuffle his pack again. Goalkeeper Rob Elliot is in contention after recovering from a knee injury and central defender Grant Hanley is in line for another start.
Striker Aleksandar Mitrovic could return after having stitches removed from the knee injury he suffered at Birmingham on January 7, while midfielder Jack Colback is hoping to be available after missing last weekend's 4-0 win over Rotherham through illness. Defender Jesus Gamez (collarbone) is making good progress.
The game will come too early for Dwight Gayle (hamstring), while full-back Vurnon Anita (ankle) and midfielder Rolando Aarons (knee) are still out. Chancel Mbemba, Christian Atsu and Mohamed Diame remain on African Nations Cup duty.