Philippe Coutinho will be missing but manager Jurgen Klopp insists he will play his strongest available side against Everton.
The Brazil international, along with top scorer Mohamed Salah, are both injured while the Reds boss has yet to decide whether to give the world's most expensive defender, Virgil van Dijk, his debut after a £75million move from Southampton.
It is debatable whether Coutinho would have played in any case considering his workload over the last month but a thigh problem, plus speculation about a renewed bid from Barcelona to eclipse the £118m which was offered in August, have left his short and long-term future in doubt.
Klopp brushed aside questions about the 25-year-old as he is keen to concentrate on beating Everton at Anfield on Friday night.
"The line-up will be a line-up that shows all the respect that we have for the FA Cup," he said.
"I know that a few people have said that I don't respect the cup enough, but that's not the truth. Maybe we have to make that a bit more obvious.
"If we play two days later maybe I consider a different team but we always try to do it. Afterwards we get judged - wrong line-up, right line-up.
"It will be the strongest line-up for sure."