Saints are assessing the extent of Shane Long's hamstring strain but are confident on Sofiane Boufal and Jay Rodriguez's fitness.
Boufal and Rodriguez have been working at Saints' Staplewood training ground without problems during the international break and are raring to go when Burnley visit St Mary's on Sunday.
Long appeared to pull up with a hamstring strain in the Republic of Ireland's 3-1 win over Moldova in Chisinau this week.
The ex-Hull City and West Brom star has returned to the club to have the injury assessed but the scan results are not yet known.
Injuries to Long and England defender Ryan Bertrand could mean there are opportunities for some of Saints' talented development squad with Sam McQueen tipped to get some first-team minutes in the next few matches.