Manolo Gabbiadini could come into Mauricio Pellegrino's reckoning to start at West Brom in their FA Cup clash on Saturday.
The former Napoli man impressed in the second half of last season following his move to the club, scoring four goals, but his game-time has dried up recently as Pellegrino has favoured record-signing Guido Carrillo, Shane Long and Charlie Austin up front instead.
But with Shane Long battling a leg problem to be fit in time the Italian striker is likely to play and Mario Lemina has recovered from dizzy spells though, and is expected to feature in the midlands.
Pellegrino believes Saints must go all-out for victory this weekend, even though Premier League survival remains the clear overall priority.
'We have to understand now when you've got this possibility, the cup is an amazing thing,' said Pellegrino.
'In one game a lot of things can happen, one small thing can decide the draw, but you have to be prepared for this situation.
'In the recent two weeks we've had a game against them, but I imagine both teams will try to adjust to try to improve.
'And when you've got good knowledge about the opponent it will be really tight.
'We have to try to keep going in our way, but I imagine a really tough game.
'We want to move forward to the next round. Also it can help us to improve as a team, to introduce some players that didn't play too much in the recent game.
'It can help us to believe more in our improvements since January.
'For those aspects it will be important to play seriously, try to win the game, try to do our best, and any of both teams got nothing to lose.
'You have to go forward because it's like a final. We've got this possibility and it's amazing.'