Everton's Oumar Niasse becomes the first Premier League player to be suspended for diving when he misses Sunday's trip to Southampton.
Niasse was found guilty of deceiving the referee to win a penalty against Crystal Palace and has been hit with a two-game ban.
Caretaker manager David Unsworth will make sweeping changes to the side humbled 5-1 by Atalanta on Thursday.
Tom Davies is another who is suspended and there are questions over Phil Jagielka (groin) and Morgan Schneiderlin (toe), while Ross Barkley remains a long-term absentee.
The Toffees lost 1-0 at St Mary’s last term but Unsworth will be looking for a response from his players on Sunday, in what could turn out to be his final game in temporary charge.
Provisional squad: Pickford, Robles, Williams, Keane, Baines, Martina, Jagielka, Kenny, Gueye, Baningime, Besic, Schneiderlin, Mirallas, Lennon, Lookman, Vlasic, Sigurdsson, Klaassen, Rooney, Calvert-Lewin, Sandro.